Asia flow chemistry systems use a range of reactors, these include glass microreactors, tube reactors and column reactors in a range of configurations and sizes. These reactors are optimized for heat and mass transfer, allowing for the greatest flexibility when designing a flow chemistry experiment. They are also highly chemically compatible.
The Asia Microreactors are chemically resistant, transparent, robust flow reactors for solution phase chemistry. They offer a wide temperature and pressure range. The design results in extremely fast and reproducible mixing, rapid heat transfer and minimized back pressure due to flow.
The glass chip is supplied in a holder which enables a number of benefits such as the quick connection of fluid pipes via the Chip Header (2100147), physical durability, and thermal insulation. The holder also allows the microreactor to be heated or cooled by clipping it into the Asia Chip Climate Controller or Asia Heater.
Three different reactor volumes (62.5 µL, 250 µL, and 1000 µL) are available giving a range of reaction times (the residence time of the chemicals within the reactor changes with volume assuming the flow rate remains constant). Each volume comes in either a 2 input or 3 input version. Chip blanking plugs (2100210) can be placed into the Chip Header to reduce the number of inputs used. Note that the output of one Microreactor can be connected to the input of a second reactor to perform sequential reactions.
- Wetted materials: Glass or Quartz
- Temperature range: -20°C to +250°C (+180°C for 1000 µL Microreactor Chip)
- Maximum pressure: 30 bar (20 bar for 1000 µL Microreactor Chip)
Asia Tube Reactor
The Asia Tube Reactors are large volume microfluidic reactors designed for preparative scale solution phase chemistry. The tube reactor contains a long length tube giving higher volumes than the glass microreactors and therefore allows higher flow rates for a given residence/reaction time.
The increase in flow rate enables reaction scales of up to a kilo overnight. The tube reactors are available in 4 mL or 16 mL, in a selection of materials including PFA and Stainless Steel and for a wide range of temperatures. The PFA tube reactors have a glass insulated protective cover allowing total visualization of the reaction.
- Wetted materials: PFA or 316 Stainless Steel
- Maximum temperature: 125°C (PFA) or 250°C (Stainless Steel)
- Maximum pressure: 10 bar (PFA) or 30 bar (Stainless Steel)
Asia Column Reactor and Asia Solid Phase Reactors
Asia Column Reactors are used within an Asia system to allow the use of solid phase chemistry such as catalysts, solid-supported reagents or scavengers. The columns can be heated by mounting on the Asia Heater using the Solid Phase Adaptor.
There are 4 different diameter columns, each 100 mm long offering a wide range of volumes. Optional adjustable ends allow columns to be partially filled.
- Wetted materials: Glass, PTFE
- Size 1: 0.7 mL
- Size 2: 2.4 mL
- Size 3: 5.6 mL
- Size 4: 12 mL
- Maximum temperature: 150ºC